When a street-smart FBI agent is sent to Georgia to protect a beautiful single mother and her son from an escaped convict, he is forced to impersonate a crass Southern granny known as Big Momma in order to remain incognito.
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Martin Lawrence as Malcolm Turner
Nia Long as Sherry Pierce
Paul Giamatti as John
Jascha Washington as Trent Pierce
Terrence Howard as Lester Vesco
Anthony Anderson as Nolan
Carl Wright as Ben Rawley
Phyllis Applegate as Sadie
Starletta DuPois as Miss Patterson
Nicole Prescott as Lena
Octavia Spencer as Twila
Tichina Arnold as Ritha
Cedric the Entertainer as Reverend
Philip Tan as Kang
Edwin Hodge as Basketball Teen #1
Aldis Hodge as Basketball Teen #2
Brian Palermo as Cazwell
Brian Paul Stuart as Prison Doctor
Tameka Holmes as Choir #2
Ellis Hall as Organist
Debby Gaudet as Bingo Staffer
Phil Hawn as Mailman
Jay So as High Roller
J.T. Thibodeau as Bank Robber
Arnold Chon as Kang's Bodyguard (uncredited)
Keith Cooke as Kang Fight Club Member (uncredited)