Virginia, 1803. After the United States of America acquires the inmense Louisiana territory from France, a great expedition, led by William Lewis and Meriwether Clark, is sent to survey the new lands and go where no white man has gone before.
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Fred MacMurray as Cpt. Meriwether Lewis
Charlton Heston as Lt. William Clark
Donna Reed as Sacajawea
Barbara Hale as Julia Hancock
William Demarest as Sgt. Gass
Alan Reed as Charbonneau
Eduardo Noriega as Chief Cameahwait
Larry Pennell as Wild Eagle
Herbert Heyes as President Thomas Jefferson
Lester Matthews as Mr. Hancock
Argentina Brunetti as Shoshone Woman (uncredited)
Julia Montoya as Crow Woman (uncredited)
Ralph Moody as Chief Le Borgne (uncredited)
William Phipps as Night Camp Sentry (uncredited)
Walter Reed as Helmsman Cruzatte (uncredited)
Bill Walker as Tom (uncredited)
Helen Wallace as Mrs. Martha Hancock (uncredited)
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Rudolph Maté Director
Charles C. Coleman Second Unit Director
William C. Thomas Producer
A. Earl Hedrick Art Direction
Gene Merritt Sound Recordist
William H. Pine Producer
Daniel L. Fapp Director of Photography
Hans J. Salter Original Music Composer
Gene Garvin Sound Recordist
Edmund H. North Screenplay
Donald R. O. Hatswell Technical Advisor
William Williams Second Unit Director of Photography