Dr. Tremayne is an enigmatic psychiatrist running an asylum that houses four very special cases. Visited by his colleague Nicholas, Tremayne explains his amazing and controversial theories as to why each of the four patients went mad.
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Jack Hawkins as Dr. Nicholas
Donald Pleasence as Prof. R.C. Tremayne
Georgia Brown as Fay Patterson (segment "Mr. Tiger")
Donald Houston as Sam Patterson (segment "Mr. Tiger")
Russell Lewis as Paul (segment "Mr. Tiger")
David Wood as Tutor (segment "Mr. Tiger")
Suzy Kendall as Ann / Beatrice (segment "Penny Farthing")
Peter McEnery as Timothy Patrick (segment "Penny Farthing")
Neil Kennedy as 1st Removal Men (segment "Penny Farthing")
Richard Connaught as 2nd Removal Man (segment "Penny Farthing")
Beth Morris as Polly (segment "Penny Farthing")
Frank Forsyth as Uncle Albert (segment "Penny Farthing")
Joan Collins as Bella Thompson (segment "Mel")
Michael Jayston as Brian (segment "Mel")
Kim Novak as Auriol (segment "Luau")
Michael Petrovitch as Kimo (segment "Luau")
Mary Tamm as Ginny (segment "Luau")
Lesley Nunnerley as Vera (segment "Luau")
Leon Lissek as Keoki (segment "Luau")
Zohra Sehgal as Malia (segment "Luau")
Charles Gray as Nicholas (Clinic Link Episodes segment) (voice)