Frankenstein's unscrupulous colleague, Dr. Bohmer, plans to transplant Ygor's brain so he can rule the world using the monster's body, but the plan goes sour when he turns malevolent and goes on a rampage.
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Cedric Hardwicke as Dr. Ludwig Frankenstein / Dr. Henry Frankenstein (ghostly image)
Ralph Bellamy as Erik Ernst
Lionel Atwill as Dr. Bohmer
Bela Lugosi as Ygor
Evelyn Ankers as Elsa Frankenstein
Lon Chaney Jr. as The Frankenstein Monster
Janet Ann Gallow as Cloestine Hussman
Barton Yarborough as Dr. Kettering
Doris Lloyd as Martha the Housekeeper
Leyland Hodgson as Chief Constable
Olaf Hytten as Adolph Hussman
Holmes Herbert as Magistrate
Richard Alexander as Villager at Council Meeting (uncredited)
Lionel Belmore as Councilman (uncredited)
Chet Brandenburg as Villager (uncredited)
Colin Clive as Dr. Henry Frankenstein (flashback) (uncredited)
Harry Cording as Mob Leader (uncredited)
George Eldredge as Constable (uncredited)
Dwight Frye as Villager at Meeting / Grave Robber (flashback) (uncredited)
Lawrence Grant as Mayor (uncredited)
Otto Hoffman as Villager (uncredited)
Brandon Hurst as Hans, Villager at Council Meeting (uncredited)
Michael Mark as Councilman (uncredited)
Jimmy Phillips as Boy Playing Indian (uncredited)
William Smith as Boy (uncredited)
Ernie Stanton as Constable (uncredited)
Julius Tannen as Sektal (uncredited)
Harry Tenbrook as Villager at Hearing (uncredited)
Glen Walters as Mother of Hungry Children (uncredited)