A horrific explosion creates a dimensional portal between Tromaville and its dimensional mirror image, Amortville. While the Toxie is trapped in the mirror dimension, Tromaville comes under the control of his evil doppelganger, the Noxious Offender.
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David Mattey as Toxic Avenger / Noxious Offender
Debbie Rochon as Ms. Weiner
Clyde Lewis as Toxie (voice)
Heidi Sjursen as Sarah / Claire
Ron Jeremy as Mayor Goldberg
Tom Fulp as Painter
Paul Kyrmse as Sgt. Kabukiman / Evil Kabukiman
Stan Lee as Prologue / Epilogue Narrator
Joe Fleishaker as Chester / Lardass
Dan Snow as Sgt. Kazinski
Michael Budinger as Tito
Lisa Terezakis as Sweetie Honey
Barry Brisco as Pompey
Corey Feldman as Sarah's Gynecologist
Trent Haaga as Tex Diaper
Mark Torgl as Evil Melvin
Rick Collins as Amortville Police Chief
Mitch Cohen as Lucifer
Lisa Gaye as Abortion Counselor
James Gunn as Dr. Flem Hocking
Al Goldstein as Press Secretary
Taylor Mead as Award Presenter
Yaniv Sharon as Rex Diaper
Will Keenan as Man Hit by Car
Melissa Bacelar as Dr. Hocking's Nurse
Jasi Cotton Lanier as Wet Lesbian
Lemmy Kilmister as Good Lemmy / Bad Lemmy
Julie Strain as Herself (Facelift Death)
Kevin Eastman as Himself (Breast Smoosh Death)
Tiffany Shepis as Beautiful Interpretative Dancer
Eli Roth as Beautiful Young Boy
Hugh Hefner as President of the United States
Charlotte Kaufman as Tromaville / Amortville Citizen
Lloyd Kaufman as Man in Public Service Announcement