Famous and wealthy funnyman George Simmons doesn't give much thought to how he treats people until a doctor delivers stunning health news, forcing George to reevaluate his priorities with a little help from aspiring stand-up comic Ira.
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Adam Sandler as George Simmons
Seth Rogen as Ira Wright
Leslie Mann as Laura
Eric Bana as Clarke
Jonah Hill as Leo Koenig
Jason Schwartzman as Mark Taylor Jackson
Aubrey Plaza as Daisy Danby
RZA as Chuck
Aziz Ansari as Randy
Maude Apatow as Mable
Iris Apatow as Ingrid
Torsten Voges as Dr. Lars
Allan Wasserman as Dr. Stevens
Rod Man as Rod Man
Wayne Federman as Comedy & Magic Manager
Mike O'Connell as MySpace Escort
James Taylor as James Taylor
Nicole Parker as Dawn
Nydia McFadden as Mandy
Andy Dick as Andy Dick
Charles Fleischer as Charles Fleischer
Nicol Paone as George's Sister
George Coe as George's Dad
Budd Friedman as Budd Friedman
Monty Hoffman as Monty Hoffman
Carol Leifer as Carol Leifer
Paul Reiser as Paul Reiser
Mark Schiff as Mark Schiff
George Wallace as George Wallace
Norm Macdonald as Norm Macdonald
Dave Attell as Dave Attell
Sarah Silverman as Sarah Silverman
Bryan Batt as George's Agent
Maggie Siff as Rachel
Eminem as Eminem
Ray Romano as Ray Romano
Jon Brion as Jon Brion
Sebastian Steinberg as Sebastian Steinberg
James Gadson as James Gadson
Arshad Aslam as Yo Teach Cast Member
Bo Burnham as Yo Teach Cast Member
Miki Ishikawa as Yo Teach Cast Member
Kenny Copeland Jr. as Yo Teach Cast Member
Calvin Sykes as Yo Teach Cast Member
Ca'Shawn Sims as Yo Teach Cast Member
Mandi Kreisher as Yo Teach Cast Member
Phillip Andre Botello as Yo Teach Cast Member
Carla Gallo as Miss Pruitt on Yo Teach
Ernest Lee Thomas as Yo Teach Principal
Tonita Castro as Bonita
Carlos Andrade as Gardener
Steve Bannos as Deli Manager
Justin Long as Re-Do Guy
Lucas Astrom as College Guy with Camera
Tyler Spindel as College Guy with Camera
Deamor Yi as 8-Year-Old Girl Fan
Elaine Kao as Mom with Camera
King Kedar as Family with Camera
Andre Butler Jr. as Family with Camera
Tanya Acker as Family with Camera
Jarrett Grode as Magician
Qiana Chase as Chuck's Wife
Tom Anderson as Tom Anderson
John Hartmann as Private Jet Pilot
Dave Rath as San Francisco Theatre Manager
Dan Harmon as Paparazzi at Medical Center
Brandon Cournoyer as Paparazzi at Medical Center
Kyle Kinane as Paparazzi at Medical Center
Mark Cohen as Emcee at Improv
Denise Meyerson as Deli Customer
Joanie Marx as Deli Customer
Adam J. Bernstein as Hot Dog-Eating Champion's Son
Da'Vone McDonald as Hot Dog-Eating Co-Star
Orny Adams as Orny Adams
Al Lubel as Al Lubel
Jerry Minor as Jerry Minor
Eleanor Zee as George's Mom
Ben Meyerson as George's Brother-In-Law
Sammy Jack as George's Young Nephew
Kim Taylor as Kim Taylor
Andrea Zonn as Andrea Zonn
Kate Markowitz as Kate Markowitz
Arnold McCuller as Arnold McCuller
Larry Goldings as Larry Goldings
Luis Conte as Luis Conte
Russ Kunkel as Russ Kunkel
Brad Grunberg as Comedy & Magic Club Audience
Brian Lally as Comedy & Magic Club Audience
Jimmy Johnson as Jimmy Johnson
Janeane Garofalo as Friend in video (archive footage) (uncredited)
Ben Stiller as Friend in video (archive footage) (uncredited)
Judd Apatow as Friend in video (voice) (archive footage) (uncredited)