In the midst of World War II, Sherlock Holmes rescues the Swiss inventor of a new bomb-sight from the Gestapo and brings him to England, where he quickly falls into the clutches of the evil Professor Moriarty.
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Basil Rathbone as Sherlock Holmes
Nigel Bruce as Doctor Watson
Lionel Atwill as Professor Moriarty
William Post Jr. as Dr. Franz Tobel
Kaaren Verne as Charlotte Eberli
Dennis Hoey as Inspector Lestrade
Holmes Herbert as Sir Reginald
Mary Gordon as Mrs. Hudson
Harry Cording as Jack Brady (uncredited)
Harold De Becker as Peg Leg (uncredited)
Paul Fix as Mueller (uncredited)
Henry Victor as Professor Frederic Hoffner (uncredited)
John Burton as RAF Officer (uncredited)
Paul Bryar as Swiss Waiter (uncredited)
Whit Bissell as London Bobbie (uncredited)
Rudolph Anders as Braun (uncredited)
Colin Kenny as Scotland Yard Detective (uncredited)