Loosely based on the true-life tale of Ron Woodroof, a drug-taking, women-loving, homophobic man who in 1986 was diagnosed with HIV/AIDS and given thirty days to live.
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Matthew McConaughey as Ron Woodroof
Jennifer Garner as Eve
Jared Leto as Rayon
Denis O'Hare as Dr. Sevard
Steve Zahn as Tucker
Michael O'Neill as Richard Barkley
Dallas Roberts as David Wayne
Griffin Dunne as Dr. Vass
Kevin Rankin as T.J.
Donna DuPlantier as Nurse Frazin
Deneen Tyler as Denise
J.D. Evermore as Clint
Ian Casselberry as Hispanic Orderly
Noelle Wilcox as Kelly
Bradford Cox as Sunny
Rick Espaillat as Michael
Lawrence Turner as Foreman
Lucius Falick as Freddie
James DuMont as Rayon's Father
Jane McNeill as Francine Suskind
Don Brady as Tucker's Father
Matthew Thompson as Effeminate Man
Tony Bentley as Judge
Sean Boyd as Border Agent
Rachel Wulff as News Anchor
Neeona Neal as Stripper
Scott Takeda as Mr. Yamata
Jonathan Tabler as Rick Ferris
Joji Yoshida as Dr. Hiroshi
Carl Palmer as FDA Customs Agent
Martin Covert as Ian
Douglas M. Griffin as Rog
David Lichtenstein as Cop
Craig Borten as Quicksilver Cowboy
Henry Frost as Gay Cowboy
Arthur Smith as Rodeo Announcer
Adam Dunn as Neddie Jay (uncredited)
Juliet Reeves London as Rodeo Girl (uncredited)
Jeanine Hill as Rodeo Girl (uncredited)
Sarah Eilts as Ron's Hooker (uncredited)
Lily Virginia Filson as Dancer (uncredited)
Steffie Grote as The Girl With The Snake Tattoo (uncredited)