As Father Severino Mallari, a 19th century priest during the Spanish occupation, descends into madness, his life and work as a parish priest in Pampanga is recounted, where he reportedly murdered 57 people to aid his ailing mother.
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Piolo Pascual as Jonathan / John Rey / Severino
Gloria Diaz as Doña Facunda
Janella Salvador as Agnes
JC Santos as Brother Lucas
Elisse Joson as Felicity
Vangie Labalan as Old Maria Capac
Bart Guingona as Ruizmayor
Geraldine Villamil as Young Maria Capac (as Ge Villamil)
Raffy Tejada as Father Mac
Chrome Cosio as Sergeant Sancho
Lao Rodriguez as Sergeant Vizbal
Tommy Alejandrino as Didi
Ron Angeles as Juancho Kuchero
Audrey Alquiroz as Nieves
Angie Castrence as Manang Mes
James Fajardo as Young Jonathan (as James Clarence Fajardo)
Angellie Nicholle Sanoy as Amal
John Christopher Ventura as Xoxo
Cassandra Lavarias as Linggit
Alijah Abatayo as Naruto (as Alijah Mishael A. Abatayo)