Remember that really cute girl/guy who said they'd call – and didn't? Maybe they lost your number. Maybe they're in the hospital. Maybe they're awed by your looks, brains or success. Or maybe... They're just not that into you.
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Ginnifer Goodwin as Gigi Phillips
Justin Long as Alex
Bradley Cooper as Ben Gunders
Scarlett Johansson as Anna Marks
Jennifer Connelly as Janine Gunders
Jennifer Aniston as Beth Murphy
Ben Affleck as Neil
Drew Barrymore as Mary Harris
Kevin Connolly as Conor Barry
Kris Kristofferson as Ken Murphy
Sasha Alexander as Catherine
Wilson Cruz as Nathan
Hedy Burress as Laura Murphy
Leonardo Nam as Joshua Nguyen
Busy Philipps as Kelli Ann
Brooke Bloom as Paige Murphy
Luis Guzmán as Javier
Cory Hardrict as Tyrone
Natasha Leggero as Amber Gnech
Peter O'Meara as Bill
Rod Keller as Bruce
Brandon Keener as Jarrad
Rene Lopez as Gregory
John Ross Bowie as Dan
Mike Beaver as Cousin Jay
Kai Lennox as Devon
Shane Edelman as George
Stephen Jared as Steven
Bill Brochtrup as Larry
Jason Roth as Trent
Corey Pearson as Jude
Googy Gress as Cousin Dominic
Angela Shelton as Angela
Frances Callier as Frances
Morgan Lily as 5 yr. old Girl
Trenton Rogers as 6 yr. old Boy
Annie Ilonzeh as Hot Girl
Zoe Jarman as Sorority Girl
Délé Ogundiran as African Woman
Joan Blair as Emotionless Cashier
Michelle Carmichael as Mother
Jasmine Woods as Crying 20-Something
Sabrina Revelle as Consoling Friend
Alia Rhiana Eckerman as Sorority Girl
Julia Pennington as Sous Chef
Renee Scott as Sous Chef
Chihiro Fujii as Tokyo Girl
Sachiko Ishida as Tokyo Girl
Claudia DiMartino as Jogger
Carmen Gloria Pérez as Army Recruit
Traycee King as Army Recruit
Ali Afshar as Skip
Anna Bugarin as Yoga Teacher
Nicole Steinwedell as 'No Spark' Girl
Melanie Stephens as Waitress #2
Sydney Stutterheim as Tall Girl
Gina Limbrick as Restaurant Patron (uncredited)
Natalina Maggio as Bar Girl (uncredited)
Kim McVicar as Bad Dancer (uncredited)
Brittani Noel as Consoling Friend #2 (uncredited)
Cristine Rose as Wealthy Divorcee (uncredited)
Elizabeth Russo as Waitress (uncredited)
Jana Savage as Yoga Student (uncredited)
Melissa Goodwin Shepherd as Party Goer (uncredited)
Alex Spencer as Yoga Student (uncredited)
Carly Steel as Party Girl #2 (uncredited)
Karmyn Tyler as Yoga Student (uncredited)
Sandra Valladares as Restaurant patron (uncredited)